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                          September 29, 2021

       Stephen T. Worland, Ph.D.
       Chief Executive Officer
       eFFECTOR Therapeutics, Inc.
       11120 Roselle Street, Suite A
       San Diego, CA 92121

                                                        Re: eFFECTOR
Therapeutics, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed September 23,
2021
                                                            File No. 333-259751

       Dear Dr. Worland:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Deanna
Virginio at 202-551-4530 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Matthew T. Bush, Esq.