United States securities and exchange commission logo

                          January 31, 2022

       Steven T. Worland
       Chief Executive Officer
       eFFECTOR Therapeutics, Inc.
       142 North Cedros Avenue, Suite B
       Solana Beach, California 92075

                                                        Re: eFFECTOR
Therapeutics, Inc.
Statement on Form S-1
                                                            Filed January 25,
                                                            File No. 333-262339

       Dear Mr. Worland:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jordan
Nimitz at 202-551-5831 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences